Airborne environmental injuries and human health.

The concept that the environment in which we live can have detrimental effects on our health has existed for centuries. Obvious examples of substances that can cause human diseases include infectious agents, poisons, chemicals and other noxious agents, drugs, and physical stimuli such as bright lights and loud sounds. Some less obvious agents can include allergens, nontangible agents such as colorless, odorless gases and aerosolized toxins. In recent decades, humans have developed various new materials and compounds. Additionally, we are now producing known compounds, and even naturally occurring substances, in vastly increased amounts. Many of these substances are generally believed to threaten the health of our environment. However, there is also a considerable amount of hype and exaggeration regarding some of these agents (e.g., mold) that is unsubstantiated. This article extensively reviews the data on a large number of airborne-related illnesses and attempted to place scientific reality in the context of clinical medicine

Enhancing the Well-being of Older Adults and Young Adults with Developmental Disabilities through Participation in an Intergenerational Community Garden: Participatory Action Research

The purpose of this Participatory Action Research (PAR) study was to discover ways to enhance well-being in young adults with DD and older adults in the Oak Grove community. This dissertation details how PAR was used in the Oak Grove community to identify ways to enhance purpose and meaningful activity for older adults while developing positive relationships with younger adults with DD through qualitative methods. Ryff and Keyes (1995) discovered that although some elements of well-being remain stable as a person ages, purpose-in-life drops significantly in older adults. In addition, young adults with developmental disabilities (DD) lack meaningful relationships, which negatively impacts their well-being (Mazurek, 2014). The data echoes the reported loneliness in young adults with DD in Oak Grove (the location of this study). Several older adults have purposefully tried to address this loneliness in young adults through inclusion in volunteer work; however, this has been on an intermittent basis and the need for meaningful relationships remains. Analyses of the data revealed ways to enlist the wisdom and knowledge of older adults to enhance the well-being of young adults with DD and consequently enhance the well-being of the older adult as well. Themes that were discovered in the data include the five elements of the Well-being Theory as they relate to the people of Oak Grove, specifically: engagement, positive relationships, positive emotion, purpose and meaning, and accomplishment (Seligman, 2011). In addition, multiple aspects of the unique nature of young adults with DD were revealed; the term exceptional people was used to identify this theme. Other important findings include the need for policy development for transportation for people with disabilities, the need for development of intergenerational activities, and the importance for further research

Dynamics from diffraction

A model-independent approach for the extraction of detailed lattice dynamical information from neutron powder diffraction data is described. The technique is based on a statistical analysis of atomistic configurations generated using reverse Monte Carlo structural refinement. Phonon dispersion curves extracted in this way are shown to reproduce many of the important features found in those determined independently using neutron triple-axis spectroscopy. The extent to which diffraction data are sensitive to lattice dynamics is explored in a range of materials. The prospect that such detailed dynamical information might be accessible using comparatively facile experiments such as neutron powder diffraction is incredibly valuable when studying systems for which established spectroscopic methods are prohibitive or inappropriate

A zinc transporter gene required for development of the nervous system.

The essentiality of zinc for normal brain development is well established. It has been suggested that primary and secondary zinc deficiencies can contribute to the occurrence of numerous human birth defects, including many involving the central nervous system. In a recent study, we searched for zinc transporter genes that were critical for neurodevelopment. We confirmed that ZIP12 is a zinc transporter encoded by the gene slc39a12 that is highly expressed in the central nervous systems of human, mouse, and frog (Xenopus tropicalis).Using loss-of-function methods, we determined that ZIP12 is required for neuronal differentiation and neurite outgrowth and necessary for neurulation and embryonic viability. These results highlight an essential need for zinc regulation during embryogenesis and nervous system development. We suggest that slc39a12 is a candidate gene for inherited neurodevelopmental defects in humans